Title : Progesterone production by human granulosa cells cultured in serum free medium: effects of gonadotrophins and insulin-like growth factor I (IGF-I).

Pub. Date : 1991 Sep

PMID : 1806564






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 By comparison, the effects of IGF-I on progesterone production were not marked, being absent in 80% of the follicles tested. Progesterone insulin like growth factor 1 Homo sapiens
2 However, granulosa cells from healthy follicles co-incubated with IGF-I and FSH or HCG produced more progesterone compared with cells treated with the gonadotrophins alone; this effect of IGF-I was dose dependent (ED50 of IGF-I = 10 ng/ml). Progesterone insulin like growth factor 1 Homo sapiens
3 However, granulosa cells from healthy follicles co-incubated with IGF-I and FSH or HCG produced more progesterone compared with cells treated with the gonadotrophins alone; this effect of IGF-I was dose dependent (ED50 of IGF-I = 10 ng/ml). Progesterone insulin like growth factor 1 Homo sapiens
4 However, granulosa cells from healthy follicles co-incubated with IGF-I and FSH or HCG produced more progesterone compared with cells treated with the gonadotrophins alone; this effect of IGF-I was dose dependent (ED50 of IGF-I = 10 ng/ml). Progesterone insulin like growth factor 1 Homo sapiens