Pub. Date : 2008 Mar
PMID : 18065393
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | LPA-induced secretion of transforming growth factor (TGF)-beta1 in hADSCs, and pretreatment of the cells with SB431542, a TGF-beta type I receptor kinase inhibitor, or anti-TGF-beta1 neutralizing antibody inhibited the LPA-induced expression of alpha-SMA and phosphorylation of Smad2. | lysophosphatidic acid | transforming growth factor beta 1 | Homo sapiens |
| 2 | These results suggest that cancer-derived LPA stimulates differentiation of hADSCs to myofibroblast-like cells and increases SDF-1 expression through activating autocrine TGF-beta1-Smad signaling pathway. | lysophosphatidic acid | transforming growth factor beta 1 | Homo sapiens |