Title : Somatotropes maintain their immature cells through Insulin-like growth factor I (IGF-I).

Pub. Date : 2007 Fall

PMID : 18058266






6 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In addition, GH and insulin-like growth factor I (IGF-I) stimulated the growth of MtT/E cells. monooxyethylene trimethylolpropane tristearate insulin-like growth factor 1 Rattus norvegicus
2 In addition, GH and insulin-like growth factor I (IGF-I) stimulated the growth of MtT/E cells. monooxyethylene trimethylolpropane tristearate insulin-like growth factor 1 Rattus norvegicus
3 The messenger RNAs (mRNAs) of receptors for IGF-I and GH were expressed in the MtT/E cells. monooxyethylene trimethylolpropane tristearate insulin-like growth factor 1 Rattus norvegicus
4 Therefore, we concluded that somatotropes (MtT/S) maintain their progenitor cells (MtT/E) through the GH-IGF-I signaling and IGF-I directly, which might be involved in the maintenance of progenitors of GH-producing cells and might contribute to pituitary tumor development. monooxyethylene trimethylolpropane tristearate insulin-like growth factor 1 Rattus norvegicus
5 Therefore, we concluded that somatotropes (MtT/S) maintain their progenitor cells (MtT/E) through the GH-IGF-I signaling and IGF-I directly, which might be involved in the maintenance of progenitors of GH-producing cells and might contribute to pituitary tumor development. monooxyethylene trimethylolpropane tristearate insulin-like growth factor 1 Rattus norvegicus
6 Therefore, we concluded that somatotropes (MtT/S) maintain their progenitor cells (MtT/E) through the GH-IGF-I signaling and IGF-I directly, which might be involved in the maintenance of progenitors of GH-producing cells and might contribute to pituitary tumor development. monooxyethylene trimethylolpropane tristearate insulin-like growth factor 1 Rattus norvegicus