Title : Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress.

Pub. Date : 2008 Feb 15

PMID : 18056705






3 Functional Relationships(s)
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1 In this study, we have found that glucose depletion promotes the phosphorylation of AMP-activated protein kinase catalytic subunit alpha (AMPKalpha) in association with a significant up-regulation of p53, thereby inducing p53-dependent apoptosis in vivo and in vitro. Glucose tumor protein p53 Homo sapiens
2 In this study, we have found that glucose depletion promotes the phosphorylation of AMP-activated protein kinase catalytic subunit alpha (AMPKalpha) in association with a significant up-regulation of p53, thereby inducing p53-dependent apoptosis in vivo and in vitro. Glucose tumor protein p53 Homo sapiens
3 Small interference RNA-mediated knockdown of p53 caused an inhibition of apoptosis following glucose depletion. Glucose tumor protein p53 Homo sapiens