Title : Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy.

Pub. Date : 2007 Nov

PMID : 18056045






2 Functional Relationships(s)
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1 The inhibitory effects of the nitrogen-containing BPs (including alendronate, risedronate, ibandronate, and zoledronate) on osteoclasts appear to result from their inhibition of farnesyl pyrophosphate synthase (FPPS), a key branch-point enzyme in the mevalonate pathway. Diphosphonates farnesyl diphosphate synthase Homo sapiens
2 The inhibitory effects of the nitrogen-containing BPs (including alendronate, risedronate, ibandronate, and zoledronate) on osteoclasts appear to result from their inhibition of farnesyl pyrophosphate synthase (FPPS), a key branch-point enzyme in the mevalonate pathway. Diphosphonates farnesyl diphosphate synthase Homo sapiens