Title : Lipid composition alters drug action at the nicotinic acetylcholine receptor.

Pub. Date : 2008 Mar

PMID : 18055762






2 Functional Relationships(s)
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1 Infrared difference spectra show that concentrations of tetracaine consistent with binding to the ion channel (<50 microM) stabilize a resting-like state when the nAChR is reconstituted into phosphatidylcholine membranes containing the anionic lipid, phosphatidic acid, but have no effect on the nAChR reconstituted into membranes lacking phosphatidic acid, either in the presence or absence of cholesterol. Tetracaine cholinergic receptor nicotinic alpha 4 subunit Homo sapiens
2 Infrared difference spectra show that concentrations of tetracaine consistent with binding to the ion channel (<50 microM) stabilize a resting-like state when the nAChR is reconstituted into phosphatidylcholine membranes containing the anionic lipid, phosphatidic acid, but have no effect on the nAChR reconstituted into membranes lacking phosphatidic acid, either in the presence or absence of cholesterol. Tetracaine cholinergic receptor nicotinic alpha 4 subunit Homo sapiens