Title : The emerging role of TRPV1 in diabetes and obesity.

Pub. Date : 2008 Jan

PMID : 18055025






2 Functional Relationships(s)
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1 Interestingly, ablation of TRPV1-positive fibers by subcutaneous capsaicin treatment not only ameliorates pancreatitis pain but also diminishes aging-associated weight gain and improves glucose tolerance both in mice on a high-fat diet and in rat models of type 2 diabetes. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
2 Ablation of nerves carrying this mutant TRPV1 by capsaicin prevents immune-mediated destruction of islet beta cells despite the persistence of diabetogenic T cells. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus