Pub. Date : 2007 Sep
PMID : 18051908
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: To observe effects of tetrandrine (Tet) on angiotensin II (Ang II)-induced cardiomyocyte hypertrophy and the activity and expression of phosphorylated ERK1/2 (p-ERK1/2). | tet | angiotensinogen | Rattus norvegicus |
| 2 | OBJECTIVE: To observe effects of tetrandrine (Tet) on angiotensin II (Ang II)-induced cardiomyocyte hypertrophy and the activity and expression of phosphorylated ERK1/2 (p-ERK1/2). | tet | angiotensinogen | Rattus norvegicus |
| 3 | RESULT: Tet can decrease Ang II-induced elevations of the pulsation rate, cell size, total protein and protein synthesis rate; inhibit the activity and expression of p-ERK1/2. | tet | angiotensinogen | Rattus norvegicus |
| 4 | CONCLUSION: The anti-hypertrophic effect of Tet on Ang II-induced cardiomyocyte hypertrophy was associated with inhibition of ERK1/2 signaling pathway. | tet | angiotensinogen | Rattus norvegicus |