Title : Folylpolyglutamate synthase and gamma-glutamyl hydrolase regulate leucovorin-enhanced 5-fluorouracil anticancer activity.

Pub. Date : 2008 Jan 25

PMID : 18035049






2 Functional Relationships(s)
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Protein Name
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1 Small-interfering RNA (siRNA) transfected into DLD-1 cells to downregulate FPGS reduced the basal level of reduced folate, the folate level after LV treatment, and the enhancement of 5-fluoro-2"-deoxyuridine (FdUrd)-induced cytotoxicity elicited by LV. Folic Acid folylpolyglutamate synthase Homo sapiens
2 Small-interfering RNA (siRNA) transfected into DLD-1 cells to downregulate FPGS reduced the basal level of reduced folate, the folate level after LV treatment, and the enhancement of 5-fluoro-2"-deoxyuridine (FdUrd)-induced cytotoxicity elicited by LV. Folic Acid folylpolyglutamate synthase Homo sapiens