Pub. Date : 2008 Feb
PMID : 18032517
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CD4 downregulation depends on a conserved (D/E)XXXL(L/I)-type dileucine motif in the C-terminal, flexible loop of Nef, which mediates binding to the clathrin adaptor complexes AP-1, AP-2, and AP-3. | dileucine | S100 calcium binding protein B | Homo sapiens |
| 2 | We also show that a dileucine motif from tyrosinase, both in its native context and in the context of Nef, can bind to AP-2 independently of a diacidic motif. | dileucine | S100 calcium binding protein B | Homo sapiens |
| 3 | These results thus identify a novel type of AP-2 interaction determinant, support the notion that AP-2 is the key clathrin adaptor for the downregulation of CD4 by Nef, and reveal a previously unrecognized diversity among dileucine sorting signals. | dileucine | S100 calcium binding protein B | Homo sapiens |