Pub. Date : 2008 Mar 1
PMID : 18031783
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Induction of apoptosis by esculetin in human leukemia U937 cells through activation of JNK and ERK. | esculetin | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Furthermore, esculetin selectively increased the phosphorylation of extracellular-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), but not that of other kinases such as Akt and p38 activation. | esculetin | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Furthermore, esculetin selectively increased the phosphorylation of extracellular-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), but not that of other kinases such as Akt and p38 activation. | esculetin | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | In addition, an ERK-specific inhibitor, PD98059, and a JNK-specific inhibitor, SP600125, showed inhibited sub-G1 phase DNA content, DNA fragmentation, caspase activation, and mitochondrial dysfunction induced by esculetin treatment. | esculetin | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | These results indicated that the JNK and ERK pathways were key regulators of apoptosis in response to esculetin in human leukemia U937 cells. | esculetin | mitogen-activated protein kinase 1 | Homo sapiens |