Title : Clinical significance of pharmacokinetic drug interactions between interferon-alpha and antineoplastic drugs.

Pub. Date : 1999 Feb

PMID : 18031118






1 Functional Relationships(s)
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1 The broad spectrum of antineoplastic drugs whose activity can be enhanced by IFNalpha argues for multiple levels of drug-drug interactions: protein binding (cisplatin), alteration in cellular uptake, modulation of drug target enzymes (dihydropyrimidine hydrogenase) and changes in biotransformation (tretinoin) or excretion. Tretinoin interferon alpha 1 Homo sapiens