Title : Signal strength dictates phosphoinositide 3-kinase contribution to Ras/extracellular signal-regulated kinase 1 and 2 activation via differential Gab1/Shp2 recruitment: consequences for resistance to epidermal growth factor receptor inhibition.

Pub. Date : 2008 Jan

PMID : 18025104






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Therefore, Ras/ERK1-2 depends on PI3K only when PIP(3) is required to recruit Gab1/Shp2, which occurs only under weak EGFR mobilization. pip(3) protein tyrosine phosphatase non-receptor type 11 Homo sapiens