Title : Forward- and reverse-synthesis of piperazinopiperidine amide analogs: a general access to structurally diverse 4-piperazinopiperidine-based CCR5 antagonists.

Pub. Date : 2007 Aug 21

PMID : 18019544






2 Functional Relationships(s)
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1 Thus, a SAR study of our synthesized piperazinopiperidine-based CCR5 antagonists was conducted with respect to the structure and configuration of the substituent on the piperazine ring. Piperazine C-C motif chemokine receptor 5 Homo sapiens
2 By using the forward-synthesis approach, the best compound in the chiral piperazine-based CCR5 antagonist series, Sch-D (Vicriviroc), was conveniently synthesized in an excellent yield. Piperazine C-C motif chemokine receptor 5 Homo sapiens