Title : Common tumour p53 mutations in immortalized cells from Hupki mice heterozygous at codon 72.

Pub. Date : 2008 Apr 24

PMID : 17998932






1 Functional Relationships(s)
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1 In cell lines ensuing from benzo(a)pyrene-treated cultures the combined p53 mutation pattern from experiments with the 3 codon 72 genotypes showed a predominance of strand-biased G to T transversions (18 of 36 mutations), and mutations recurring at smokers" lung tumour hotspot codons 157 and 273, supporting involvement of tobacco carcinogens in shaping the mutation signature in lung cancers of smokers. Benzo(a)pyrene tumor protein p53 Homo sapiens