Pub. Date : 2008 Jan 14
PMID : 17997002
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Arecoline-induced growth arrest and p21WAF1 expression are dependent on p53 in rat hepatocytes. | Arecoline | Wistar clone pR53P1 p53 pseudogene | Rattus norvegicus |
| 2 | Moreover, arecoline (0.5mM) time-dependently (8-24h) increased p53 serine 15 phosphorylation. | Arecoline | Wistar clone pR53P1 p53 pseudogene | Rattus norvegicus |
| 3 | Pifithrin-alpha (p53 inhibitor) and the loss of the two p53-binding elements in the p21(WAF1) gene promoter attenuated arecoline-induced p21(WAF1) gene transcription at 24h. | Arecoline | Wistar clone pR53P1 p53 pseudogene | Rattus norvegicus |
| 4 | Pifithrin-alpha (p53 inhibitor) and the loss of the two p53-binding elements in the p21(WAF1) gene promoter attenuated arecoline-induced p21(WAF1) gene transcription at 24h. | Arecoline | Wistar clone pR53P1 p53 pseudogene | Rattus norvegicus |
| 5 | We concluded that arecoline induces cytotoxicity, DNA damage, G(0)/G(1) cell cycle arrest, TGF-beta1, p21(WAF1) and activates p53 in Clone-9 cells. | Arecoline | Wistar clone pR53P1 p53 pseudogene | Rattus norvegicus |
| 6 | Moreover, arecoline-induced p21(WAF1) is dependent on p53 while arecoline-inhibited growth is dependent on both TGF-beta and p53. | Arecoline | Wistar clone pR53P1 p53 pseudogene | Rattus norvegicus |
| 7 | Moreover, arecoline-induced p21(WAF1) is dependent on p53 while arecoline-inhibited growth is dependent on both TGF-beta and p53. | Arecoline | Wistar clone pR53P1 p53 pseudogene | Rattus norvegicus |