Pub. Date : 2008 Feb 7
PMID : 17996964
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We investigated the in vivo efficacy of a Shh antagonist, cyclopamine, in correlation to the secondary effects induced by this treatment on gastrin levels and acid secretion. | cyclopamine | sonic hedgehog | Mus musculus |
| 2 | We showed that cyclopamine treatment induces both hypergastrinaemia and Shh, and does not inhibit Gli-1. | cyclopamine | sonic hedgehog | Mus musculus |
| 3 | Inhibition of the effect of hypergastrinaemia on the Shh pathway, in cyclopamine-treated mice, was demonstrated by use of lansoprazole which concomitantly inhibited Gli-1, and did not increase Shh production. | cyclopamine | sonic hedgehog | Mus musculus |