Title : Biochemical mechanisms underlying the pro-apoptotic activity of 7,8-dihydroxy-4-methylcoumarin in human leukemic cells.

Pub. Date : 2008 Feb 1

PMID : 17996847






1 Functional Relationships(s)
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1 The pro-apoptotic effect of DHMC was mediated by activation of the JNKs and inhibition of the ERK1/2 and PI3K/Akt pathways, with no participation of the p38 cascade after 24h of treatment. 7,8-dihydroxy-4-methylcoumarin AKT serine/threonine kinase 1 Homo sapiens