Title : A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer.

Pub. Date : 2007 Nov 9

PMID : 17996713






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Using model animal and cell studies, we then show that overexpressed 4E-BP1 and eIF4G orchestrate a hypoxia-activated switch from cap-dependent to cap-independent mRNA translation that promotes increased tumor angiogenesis and growth at the level of selective mRNA translation. cap eukaryotic translation initiation factor 4 gamma 1 Homo sapiens