Title : Potent inhibition of human cytochrome P450 3A4, 2D6, and 2C9 isoenzymes by grapefruit juice and its furocoumarins.

Pub. Date : 2007 Oct

PMID : 17995595






2 Functional Relationships(s)
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1 Potent inhibition of human cytochrome P450 3A4, 2D6, and 2C9 isoenzymes by grapefruit juice and its furocoumarins. Furocoumarins cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Seven different grapefruit and pummelo juices as well as 5 furocoumarins isolated from grapefruit juice were evaluated at different concentration on cytochrome P450 3A4 (CYP3A4), cytochrome P450 2C9 (CYP2C9), and cytochrome P450 2D6 (CYP2D6) isoenzyme activity. Furocoumarins cytochrome P450 family 3 subfamily A member 4 Homo sapiens