Title : Benzene-1,2-, 1,3-, and 1,4-di-N-substituted carbamates as conformationally constrained inhibitors of acetylcholinesterase.

Pub. Date : 2007

PMID : 17994573






1 Functional Relationships(s)
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1 Therefore, benzene-1,4-di-N-substituted carbamates (para compounds), with the angle of 180 degrees between two C(benzene)-O bonds, mimic the preferable anti C-O/C-N conformers of acetylcholine for the choline ethylene backbone in the acetylcholinesterase catalysis. Acetylcholine acetylcholinesterase (Cartwright blood group) Homo sapiens