Pub. Date : 2008 Jan 18
PMID : 17991745
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Galpha(s) repressed hydrogen peroxide-induced Bak expression by inhibiting the transcription of Bak mRNA, which resulted from the inhibition of the hydrogen peroxide-induced activation of transcription factors such as AP1, NF-kappaB, and NFAT. | Hydrogen Peroxide | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
2 | Galpha(s) repressed hydrogen peroxide-induced Bak expression by inhibiting the transcription of Bak mRNA, which resulted from the inhibition of the hydrogen peroxide-induced activation of transcription factors such as AP1, NF-kappaB, and NFAT. | Hydrogen Peroxide | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
3 | Moreover, Galpha(s) also inhibited the hydrogen peroxide-induced binding of AP1, NF-kappaB, and NFAT to the Bak promoter. | Hydrogen Peroxide | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
4 | From the results, we conclude that Galpha(s) protects neuroblastoma cells from hydrogen peroxide-induced apoptosis by repressing Bak induction, which is mediated by the inhibition of the hydrogen peroxide-induced activations of AP1, NF-kappaB, and NFAT through cAMP-PKA-CREB signaling system. | Hydrogen Peroxide | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |