Title : Stimulatory heterotrimeric GTP-binding protein inhibits hydrogen peroxide-induced apoptosis by repressing BAK induction in SH-SY5Y human neuroblastoma cells.

Pub. Date : 2008 Jan 18

PMID : 17991745






4 Functional Relationships(s)
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1 Galpha(s) repressed hydrogen peroxide-induced Bak expression by inhibiting the transcription of Bak mRNA, which resulted from the inhibition of the hydrogen peroxide-induced activation of transcription factors such as AP1, NF-kappaB, and NFAT. Hydrogen Peroxide Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 Galpha(s) repressed hydrogen peroxide-induced Bak expression by inhibiting the transcription of Bak mRNA, which resulted from the inhibition of the hydrogen peroxide-induced activation of transcription factors such as AP1, NF-kappaB, and NFAT. Hydrogen Peroxide Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
3 Moreover, Galpha(s) also inhibited the hydrogen peroxide-induced binding of AP1, NF-kappaB, and NFAT to the Bak promoter. Hydrogen Peroxide Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
4 From the results, we conclude that Galpha(s) protects neuroblastoma cells from hydrogen peroxide-induced apoptosis by repressing Bak induction, which is mediated by the inhibition of the hydrogen peroxide-induced activations of AP1, NF-kappaB, and NFAT through cAMP-PKA-CREB signaling system. Hydrogen Peroxide Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens