Title : Attenuated hypothalamo-pituitary-adrenal axis responses to immune challenge during pregnancy: the neurosteroid opioid connection.

Pub. Date : 2008 Jan 15

PMID : 17991694






1 Functional Relationships(s)
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1 Suppressed responsiveness of the CRH neurones, and hence the HPA axis, following IL-1beta in late pregnancy is explained by presynaptic inhibition of noradrenaline release in the pPVN, due to increased endogenous enkephalin and mu-opioid receptor production in brainstem NTS neurones. Norepinephrine interleukin 1 beta Rattus norvegicus