Title : Integration of cytokine biology and lipid metabolism in stroke.

Pub. Date : 2008 Jan 1

PMID : 17981627






2 Functional Relationships(s)
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Protein Name
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1 TNF-alpha and IL-1alpha/beta can induce phospholipases (A2, C, and D) and sphingomyelinases, and concomitantly proteolyse phosphatidylcholine and sphingomyelin synthesizing enzymes. Phosphatidylcholines tumor necrosis factor Homo sapiens
2 Together, these alterations contribute to loss of phosphatidylcholine and sphingomyelin after stroke that can be attenuated by inhibiting TNF-alpha or IL-1alpha/beta signaling. Phosphatidylcholines tumor necrosis factor Homo sapiens