Title : Antagonism of thromboxane receptors by diclofenac and lumiracoxib.

Pub. Date : 2007 Dec

PMID : 17965743






2 Functional Relationships(s)
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1 The selective COX-2 inhibitor lumiracoxib shared this activity profile, whereas a number of standard NSAIDs and other selective COX-2 inhibitors did not. lumiracoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 CONCLUSIONS AND IMPLICATIONS: Diclofenac and lumiracoxib, in addition to being COX unselective and highly COX-2 selective inhibitors, respectively, displayed a previously unknown pharmacological activity, namely TP receptor antagonism. lumiracoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens