Title : Identification of cytochrome P450 enzymes involved in the metabolism of the new designer drug 4'-methyl-alpha-pyrrolidinobutyrophenone.

Pub. Date : 2008 Jan

PMID : 17962373






1 Functional Relationships(s)
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Protein Name
Organism
1 At 1 microM MPBP, the chemical inhibitors quinidine (CYP2D6), fluconazole (CYP2C19), and alpha-naphthoflavone (CYP1A2) reduced metabolite formation in pooled HLM by 83, 53, and 47%, respectively, and at 50 microM MPBP by 41, 47, and 45%, respectively. alpha-naphthoflavone cytochrome P450 family 1 subfamily A member 2 Homo sapiens