Title : Inhibitory effect of citrus 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone on 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumor promotion in mice.

Pub. Date : 2007 Dec

PMID : 17962218






1 Functional Relationships(s)
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1 Pre-treatment with 5-OH-HxMF resulted in the reduction of TPA-induced nuclear translocation of nuclear factor-kappaB (NF-kappaB) subunit and DNA binding by blocking phosphorylation of inhibitor kappaB (IkappaB) alpha and p65 and subsequent degradation of IkappaBalpha. Tetradecanoylphorbol Acetate v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus