Pub. Date : 2008 Feb 1
PMID : 17951529
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway. | Tretinoin | forkhead box P3 | Homo sapiens |
| 2 | Here we show that all-trans retinoic acid (ATRA) and other agonists of the retinoic acid receptor alpha (RARalpha) inhibit the formation of Th17 cells and promote FoxP3 expression. | Tretinoin | forkhead box P3 | Homo sapiens |
| 3 | Here we show that all-trans retinoic acid (ATRA) and other agonists of the retinoic acid receptor alpha (RARalpha) inhibit the formation of Th17 cells and promote FoxP3 expression. | Tretinoin | forkhead box P3 | Homo sapiens |
| 4 | Conversely, inhibition of retinoic acid signaling constrains transforming growth factor beta (TGF-beta1) induction of FoxP3. | Tretinoin | forkhead box P3 | Homo sapiens |
| 5 | The effect of ATRA is mediated independently of IL-2, signal transducer and activator of transcription 5 (Stat5) and Stat3, representing a novel mechanism for the induction of FoxP3 in CD4 T cells. | Tretinoin | forkhead box P3 | Homo sapiens |