Title : Regulation of fibroblast growth factor-2 expression in pulmonary arterial smooth muscle cells involves increased reactive oxygen species generation.

Pub. Date : 2008 Jan

PMID : 17942638






2 Functional Relationships(s)
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1 Furthermore, FGF-2 increased HIF-1alpha protein levels and consensus HRE promoter activity in PASMC via antioxidant-sensitive mechanisms. pasmc fibroblast growth factor 2 Homo sapiens
2 Thus we conclude that FGF-2 can stimulate its own expression in PASMC via NADPH oxidase-mediated activation of ROS-sensitive transcription factors, including HIF-1alpha. pasmc fibroblast growth factor 2 Homo sapiens