Title : Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion.

Pub. Date : 2008 Jan

PMID : 17942596






1 Functional Relationships(s)
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1 We show that hydroxylation on proline 402 is altered by Ang II, decreasing pVHL binding to HIF-1alpha and allowing HIF-1alpha protein to escape subsequent ubiquitination and degradation mechanisms. Proline von Hippel-Lindau tumor suppressor Homo sapiens