Title : Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion.

Pub. Date : 2008 Jan

PMID : 17942596






2 Functional Relationships(s)
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1 Under normal oxygen conditions, HIF-1alpha, the active subunit of HIF-1, is hydroxylated on proline residues by specific HIF prolyl-hydroxylases, leading to ubiquitination and degradation by the proteasome. Proline hypoxia inducible factor 1 subunit alpha Homo sapiens
2 Under normal oxygen conditions, HIF-1alpha, the active subunit of HIF-1, is hydroxylated on proline residues by specific HIF prolyl-hydroxylases, leading to ubiquitination and degradation by the proteasome. Proline hypoxia inducible factor 1 subunit alpha Homo sapiens