Pub. Date : 2008 Jan
PMID : 17942461
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Identification through microarray gene expression analysis of cellular responses to benzo(a)pyrene and its diol-epoxide that are dependent or independent of p53. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 2 | Interestingly, DNA adduct formation after BaP, but not BPDE, exposure was p53 dependent with 10-fold lower levels detected in p53-null cells. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 3 | Interestingly, DNA adduct formation after BaP, but not BPDE, exposure was p53 dependent with 10-fold lower levels detected in p53-null cells. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 4 | Other cell lines were investigated for BaP-DNA adduct formation and in these the effect of p53 knockdown was also to reduce adduct formation. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 5 | Taken together, these results give further insight into the role of p53 in the response of human cells to BaP and BPDE and suggest that loss of this tumour suppressor can influence the metabolic activation of BaP. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 6 | Taken together, these results give further insight into the role of p53 in the response of human cells to BaP and BPDE and suggest that loss of this tumour suppressor can influence the metabolic activation of BaP. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |