Title : Comparison of the effects of two long-acting beta2-agonists on cytokine secretion by human airway epithelial cells.

Pub. Date : 2007 Oct

PMID : 17932597






3 Functional Relationships(s)
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1 METHODS: The effects of the LABAs salmeterol and formoterol on the synthesis of soluble interleukin-8 (IL-8), granulocyte-macrophage colony-stimulating factor (GM-CSF), and vascular endothelial growth factor (VEGF) in the human airway epithelial cell line A549 was investigated in vitro. Formoterol Fumarate C-X-C motif chemokine ligand 8 Homo sapiens
2 RESULTS: Both salmeterol and formoterol significantly suppressed IL-8, GM-CSF, and VEGF secretion from tumor necrosis factor-alpha-stimulated A549 cells. Formoterol Fumarate C-X-C motif chemokine ligand 8 Homo sapiens
3 Results indicated that formoterol was more potent than salmeterol in suppressing IL-8 and VEGF production. Formoterol Fumarate C-X-C motif chemokine ligand 8 Homo sapiens