Title : Pharmacogenetic study of cholesteryl ester transfer protein gene and simvastatin treatment in hypercholesterolaemic subjects.

Pub. Date : 2007 Oct

PMID : 17931083






3 Functional Relationships(s)
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1 OBJECTIVE: To examine the effect of the I405V and TaqIB polymorphisms of cholesteryl ester transfer protein (CETP) on the lipid response after simvastatin treatment in 180 hypercholesterolaemic patients. Simvastatin cholesteryl ester transfer protein Homo sapiens
2 OBJECTIVE: To examine the effect of the I405V and TaqIB polymorphisms of cholesteryl ester transfer protein (CETP) on the lipid response after simvastatin treatment in 180 hypercholesterolaemic patients. Simvastatin cholesteryl ester transfer protein Homo sapiens
3 CONCLUSIONS: The authors" findings suggest that CETP I405V polymorphism modifies the effect of simvastatin on TG reduction and HDL-C elevation; the carriers of the I allele responded better to treatment. Simvastatin cholesteryl ester transfer protein Homo sapiens