Title : HMG-CoA reductase inhibitor simvastatin inhibits cell cycle progression at the G1/S checkpoint in immortalized lymphocytes from Alzheimer's disease patients independently of cholesterol-lowering effects.

Pub. Date : 2008 Jan

PMID : 17928568






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 SIM induces a partial blockade of retinoblastoma protein phosphorylation and inhibition of cyclin E/cyclin-dependent kinase (CDK)2 activity associated with increased levels of the CDK inhibitors p21(Cip1) and p27(kip1). Simvastatin cyclin dependent kinase 2 Homo sapiens
2 SIM induces a partial blockade of retinoblastoma protein phosphorylation and inhibition of cyclin E/cyclin-dependent kinase (CDK)2 activity associated with increased levels of the CDK inhibitors p21(Cip1) and p27(kip1). Simvastatin cyclin dependent kinase 2 Homo sapiens