Pub. Date : 2007 Dec
PMID : 17928537
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Histamine enhances the production of human beta-defensin-2 in human keratinocytes. | Histamine | defensin beta 4A | Homo sapiens |
| 2 | hBD-2 induces histamine release from mast cells. | Histamine | defensin beta 4A | Homo sapiens |
| 3 | We examined the in vitro effects of histamine on hBD-2 production in normal human keratinocytes. | Histamine | defensin beta 4A | Homo sapiens |
| 4 | Histamine enhanced TNF-alpha- or IFN-gamma-induced hBD-2 secretion and mRNA expression. | Histamine | defensin beta 4A | Homo sapiens |
| 5 | Antisense oligonucleotides against NF-kappaB components p50 and p65, AP-1 components c-Jun and c-Fos, or H1 antagonist pyrilamine suppressed hBD-2 production induced by histamine plus TNF-alpha or IFN-gamma. | Histamine | defensin beta 4A | Homo sapiens |
| 6 | Antisense oligonucleotide against STAT1 only suppressed hBD-2 production induced by histamine plus IFN-gamma. | Histamine | defensin beta 4A | Homo sapiens |
| 7 | These results suggest that histamine stimulates H1 receptor and potentiates TNF-alpha- or IFN-gamma-induced hBD-2 production dependent on NF-kappaB, AP-1, or STAT1 in human keratinocytes. | Histamine | defensin beta 4A | Homo sapiens |
| 8 | Histamine may potentiate anti-microbial defense, skin inflammation, and wound repair via the induction of hBD-2. | Histamine | defensin beta 4A | Homo sapiens |