Pub. Date : 2007 Dec
PMID : 17928537
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Histamine enhanced TNF-alpha- or IFN-gamma-induced hBD-2 secretion and mRNA expression. | Histamine | interferon gamma | Homo sapiens |
| 2 | Histamine alone enhanced transcriptional activities of NF-kappaB and activator protein-1 (AP-1) and potentiated TNF-alpha-induced NF-kappaB and AP-1 activities or IFN-gamma-induced NF-kappaB and STAT1 activities. | Histamine | interferon gamma | Homo sapiens |
| 3 | Antisense oligonucleotides against NF-kappaB components p50 and p65, AP-1 components c-Jun and c-Fos, or H1 antagonist pyrilamine suppressed hBD-2 production induced by histamine plus TNF-alpha or IFN-gamma. | Histamine | interferon gamma | Homo sapiens |
| 4 | Histamine induced serine phosphorylation of inhibitory NF-kappaBalpha (IkappaBalpha) alone or together with TNF-alpha or IFN-gamma. | Histamine | interferon gamma | Homo sapiens |
| 5 | Histamine induced serine phosphorylation of STAT1 alone or together with IFN-gamma, whereas it did not further enhance IFN-gamma-induced tyrosine phosphorylation of STAT1. | Histamine | interferon gamma | Homo sapiens |
| 6 | These results suggest that histamine stimulates H1 receptor and potentiates TNF-alpha- or IFN-gamma-induced hBD-2 production dependent on NF-kappaB, AP-1, or STAT1 in human keratinocytes. | Histamine | interferon gamma | Homo sapiens |