Title : Overproduction of bioactive retinoic acid in cells expressing disease-associated mutants of retinol dehydrogenase 12.

Pub. Date : 2007 Dec 7

PMID : 17925390






1 Functional Relationships(s)
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1 Disease-associated mutants of RDH12, T49M and I51N, exhibit significant residual activity in vitro, but are unable to control retinoic acid levels in the cells because of their dramatically reduced affinity for NADPH and much lower protein expression levels. NADP retinol dehydrogenase 12 Mus musculus