Title : Loss of TP53-DNA interaction induced by p.C135R in lung cancer.

Pub. Date : 2007 Nov

PMID : 17914575






1 Functional Relationships(s)
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1 To demonstrate the degree of loss of function, functional assays in yeast and bacteria with oligonucleotides for competitive electrophoretic mobility shift assays (EMSAs) were done proving that this mutation decreases TP53 ability to bind DNA of the TP53 response element from the human p21 gene. Oligonucleotides H3 histone pseudogene 16 Homo sapiens