Title : In vivo bioactivity of interferon-beta in multiple sclerosis patients with neutralising antibodies is titre-dependent.

Pub. Date : 2008 Jan

PMID : 17911184






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Patients with NAb titres of up to 150 TRU/ml (ten times reduction units per ml) still had retained IFNbeta bioactivity, whereas greatly reduced levels of IFNbeta bioactivity were found in patients with NAbs of 150-600 TRU/ml. nab interferon beta 1 Homo sapiens
2 CONCLUSION: There is a stepwise loss of IFNbeta bioactivity with increasing NAb titres and it is possible to identify functionally critical NAb titre levels that are useful to support treatment decisions at the individual patient level. nab interferon beta 1 Homo sapiens