Title : N-phenylamine derivatives as aggregation inhibitors in cell models of tauopathy.

Pub. Date : 2007 Sep

PMID : 17908042






1 Functional Relationships(s)
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1 They are based on neuroblastoma cell lines (N2a) that inducibly express different forms of the repeat domain of tau (tau(RD)), e.g. the 4-repeat domain of tau with the wild-type sequence, the repeat domain with the DeltaK280 mutation ("pro-aggregation mutant"), or the repeat domain with DeltaK280 and two proline point mutations ("anti-aggregation mutant"). Proline microtubule associated protein tau Homo sapiens