Title : Monitoring gene therapy by external imaging of mRNA: pilot study on murine erythropoietin.

Pub. Date : 2007 Oct

PMID : 17898652






2 Functional Relationships(s)
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1 Oligonucleotides of peptide nucleic acid (PNA) type capable of antisense binding to unique murine Epo-mRNA sequences were synthesized by solid phase methods, and elongated at the N-terminus with the HIV Tat (48-60) cell penetrating peptide. Oligonucleotides erythropoietin Mus musculus
2 Downregulation of newly expressed erythropoietin protein in such cells additionally confirmed the penetration and hybridizing properties of the selected labeled oligonucleotide. Oligonucleotides erythropoietin Mus musculus