Title : Human papillomavirus E6 proteins mediate resistance to interferon-induced growth arrest through inhibition of p53 acetylation.

Pub. Date : 2007 Dec

PMID : 17898049






2 Functional Relationships(s)
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Protein Name
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1 Treatment of E7-expressing cells with interferon ultimately resulted in cellular senescence through a process that is dependent upon acetylation of p53 by p300/CBP at lysine 382. Lysine tumor protein p53 Homo sapiens
2 Finally, p53 acetylation at lysine 382 was found not to be an essential determinant of other types of senescence such as that induced by overexpression of Ras in human fibroblasts. Lysine tumor protein p53 Homo sapiens