Title : Mechanism and functional significance of Itk autophosphorylation.

Pub. Date : 2007 Nov 9

PMID : 17897671






1 Functional Relationships(s)
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1 Using an in vitro kinase assay, we show that mutation of the Itk autophosphorylation site Y180 to Phe decreases kinase activity of the full-length enzyme by increasing Km for a peptide substrate. y180 IL2 inducible T cell kinase Homo sapiens