Title : Molecular mechanism of imidapril for cardiovascular protection via inhibition of MMP-9.

Pub. Date : 2007 Dec

PMID : 17884087






3 Functional Relationships(s)
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1 Compared with the lisinopril-MMP-9 model in our previous study, imidapril was stabilized effectively on the active site with less of molecular distortions. Lisinopril matrix metallopeptidase 9 Homo sapiens
2 We also measured ACE and MMP-9 inhibitory activities of imidapril and lisinopril after myocardial infarction. Lisinopril matrix metallopeptidase 9 Homo sapiens
3 These findings show that imidapril inhibits MMP-9 directly like lisinopril and its hydrophobic interactions with the S1 site of MMP-9 would be important for enhancing inhibitory activity. Lisinopril matrix metallopeptidase 9 Homo sapiens