Title : Gonadotropin-releasing hormone neurons express K(ATP) channels that are regulated by estrogen and responsive to glucose and metabolic inhibition.

Pub. Date : 2007 Sep 19

PMID : 17881521






3 Functional Relationships(s)
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1 Whole-cell recordings from mouse enhanced green fluorescent protein-GnRH neurons revealed that the K(ATP) channel opener diazoxide induced an outward current that was antagonized by the sulfonylurea receptor 1 (SUR1) channel blocker tolbutamide. Diazoxide ATP-binding cassette, sub-family C (CFTR/MRP), member 8 Mus musculus
2 Whole-cell recordings from mouse enhanced green fluorescent protein-GnRH neurons revealed that the K(ATP) channel opener diazoxide induced an outward current that was antagonized by the sulfonylurea receptor 1 (SUR1) channel blocker tolbutamide. Diazoxide ATP-binding cassette, sub-family C (CFTR/MRP), member 8 Mus musculus
3 Single-cell reverse transcription (RT)-PCR revealed that the majority of GnRH neurons expressed Kir6.2 and SUR1 subunits, which correlated with the diazoxide/tolbutamide sensitivity. Diazoxide ATP-binding cassette, sub-family C (CFTR/MRP), member 8 Mus musculus