Title : Nicotine-induced prenatal overexposure to maternal glucocorticoid and intrauterine growth retardation in rat.

Pub. Date : 2007 Nov

PMID : 17881205






2 Functional Relationships(s)
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1 The results showed that prenatal chronic nicotine exposure causes IUGR in rats (P<0.01); in response to nicotine exposure, maternal serum corticosterone levels were elevated at mid- and late-gestations (P<0.05); mRNA expressions of StAR and P450scc increased in maternal adrenals (P<0.05 or 0.01) but decreased in fetal adrenals (P=0.16 or 0.11). Nicotine cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus
2 The results showed that prenatal chronic nicotine exposure causes IUGR in rats (P<0.01); in response to nicotine exposure, maternal serum corticosterone levels were elevated at mid- and late-gestations (P<0.05); mRNA expressions of StAR and P450scc increased in maternal adrenals (P<0.05 or 0.01) but decreased in fetal adrenals (P=0.16 or 0.11). Nicotine cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus