Title : Glycogen synthase kinase-3beta inhibition attenuates the development of bleomycin-induced lung injury.

Pub. Date : 2007 Jul-Sep

PMID : 17880775






2 Functional Relationships(s)
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1 An increase in immunoreactivity to nitrotyrosine, iNOS, TNF-alpha and IL-1beta was also observed in the lungs of BLM-treated mice. Bleomycin interleukin 1 beta Mus musculus
2 In contrast, administration of BLM-treated mice with TDZD-8 (1 mg/kg daily) significantly reduced (I) the degree of lung injury, (II) the increase in staining (immunohistochemistry) for myeloperoxidase (MPO), nitrotyrosine, iNOS, TNF-alpha and IL-1beta and (III) the degree of apoptosis, as evaluated by Bax and Bcl-2 immunoreactivity and TUNEL staining. Bleomycin interleukin 1 beta Mus musculus