Title : [Cerulenin changes apoptosis related genes expression in multiple myeloma cell line U266].

Pub. Date : 2007 Apr

PMID : 17877200






3 Functional Relationships(s)
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1 METHODS: The expression changes of 96 apoptosis related genes were analyzed by superArray cDNA in U266 cells treated with cerulenin (20 microg/ml) for 12 h. Semi-quantitative RT-PCR was used to confirm the representative expression changes genes, Rip2, caspase 9 and TRAF2. Cerulenin caspase 9 Homo sapiens
2 The expression of caspase 9 was increased markedly, indicating that mitochondria pathway played a key role in cerulenin inducing apoptosis and TRAF2 expression change suggested that nuclear factor (NF) participates in cerulenin inducing apoptosis. Cerulenin caspase 9 Homo sapiens
3 The expression of caspase 9 was increased markedly, indicating that mitochondria pathway played a key role in cerulenin inducing apoptosis and TRAF2 expression change suggested that nuclear factor (NF) participates in cerulenin inducing apoptosis. Cerulenin caspase 9 Homo sapiens