Title : Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms.

Pub. Date : 2007 Sep

PMID : 17876041






1 Functional Relationships(s)
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1 Livers from female, juvenile rats treated for 3 days with estradiol and/or with the benzothiophene SERMs arzoxifene, DMA, and F-DMA showed substantial induction of NQO1 by the benzothiophene SERMs. LY 353381 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus